Semaj Christon contributed 15 points to help the Musketeers (18-8, 8-5) retain at least a share of third place in the Big East Conference.
It was the most complete performance of the season for Davis who also had two steals, just one turnover, and went four of five from 3-point range.
Freshman guard Billy Garrett Jr. scored 16 points and Forrest Robinson added 14 points off the bench for DePaul (10-17, 2-12), which lost for the ninth straight time.
Brandon Young added 12 points for the Blue Demons who again played short-handed. For the third straight game DePaul played without star forward Cleveland Melvin who left the program for unspecified reasons after averaging 16.7 points in seven contests.